Biologics Discovery

From target biology to designed biomolecules – antibody to assembly

We start with the biology and structure, then design in the modality that fits: antibodies, peptides, proteins, and ADCs. Deliverables are designed sequences and structures.

Antibody Design Peptide Design Protein Design ADC Design

From Target to Design-Ready Candidate

With a target in mind, Arontier's structural biology and design experts consult on the design strategy and carry it through candidate design and delivery.

01
Target & Structure Analysis
The target and program goals are reviewed, the structure is predicted and optimized, and functional hotspots and epitopes are identified.
02
Candidate Design
A design strategy is developed for the target, generating candidate sequences and structures.
03
Delivery
Sequences and structures are delivered ready for synthesis and downstream experimental testing. Experimental validation can also be arranged through partner laboratories.
Discuss Your Target

Antibody Design · AphixAntibody

Rapid Antibody Hit Discovery

We review the target’s biology and structure, then design binders against it – from scratch, or from an antibody you already have.

Target Assessment
Biology and structure review to select the epitope
De Novo
Design from the target alone: IgG • Fab • scFv • VHH
Reference-Guided
Improve affinity, developability, or cross-reactivity on an existing antibody

Timeline: Typically under 2 months

De novo antibody–antigen complex

Peptide Design · AphixPeptide

Rapid Peptide Hit Discovery

Our peptide design spans antagonists to dual agonists — with structure- and sequence-based agonism prediction, confirmed by cell-based validation with no cytotoxicity.

Peptide Docking Structure
Target assessment
Site selection and functional strategy
Function
Binder, antagonist, agonist, multi-functional ligand
Chemistry
Typically ≤20 residues, with cyclization and non-canonical amino acids for stability and exposure

Timeline: Typically under 1 month

Protein Design · AphixProtein

From Minibinders to Multimeric Proteins

Design your protein of interest, regardless of size — from monomeric to multimeric proteins with desirable biophysical properties.

Minibinder
Compact scaffold for high-affinity binding
Synthetic Antigen
Redesigned antigens for improved function or vaccine safety
Multimeric Protein
Complex multi-subunit structures for the function you need
Synthetic Antigen Structure

RSV antigen redesigned to remove ERD-causing regions, with validated efficacy and toxicity profiles. Read the preprint

ADC Design · AphixADC

ADC Structure Generation

Generate antibody-drug conjugate structures across mono- and multi-specific antibody formats, with random or site-specific conjugation and a full range of drug-to-antibody ratios.

Antibody-Drug Conjugate Structure
Antibody Format
Mono & multi-specific antibody
Conjugation
Random & site-specific conjugation
DAR
0~max DAR (drug-to-antibody ratio)

Start a Program

Launch Your Biologics Discovery Program

Arontier designs biologics for targets you bring — antibodies, peptides, proteins, or ADCs — with validated hits typically in 1–2 months.

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